Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 40, Issue 9, Pages 2360-2368Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.200940294
Keywords
IL-10; LPS; Monocytes; Neutrophils; STAT3
Categories
Funding
- Ministero dell'Istruzione
- Universita e della Ricerca [PRIN 2007H9AWXY, 2006064751]
- University of Verona
- Fondazione Cariverona
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [IG5839]
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Analysis of the molecular mechanisms governing the ability of IL-10 to keep inflammation under control has highlighted the existence of a great degree of plasticity and specificity with regard to innate immune cells. In this respect, neutrophils represent a perfect example of innate immune cells conditioned by external signals (for instance, by LPS), as well as by intracellular regulatory pathways, that render them optimally responsive to IL-10 only when required. The focus of this review are the recent experimental findings that have uncovered the sophisticated and complex molecular mechanisms responsible for the modulation of pro- and anti-inflammatory cytokine production by IL-10 in neutrophils and other innate immune cells. Understanding how IL-10 exerts its anti-inflammatory response, particularly in the case of neutrophils, will provide novel clues leading, hopefully, to the therapeutic control of neutrophil-driven inflammatory reactions, such as septic infections, rheumatoid arthritis, osteoarthritis and chronic obstructive pulmonary disease.
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