Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 40, Issue 3, Pages 611-615Publisher
WILEY
DOI: 10.1002/eji.200940180
Keywords
Caspase-1; Inflammasome IL-1 beta; Nlrc4; Nlrp3
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Funding
- NIH [AI063331, AI064748]
- Arthritis Foundation
- Deutsche Forschungsgemeinschaft (DFG) Germany
- Swiss National Science Foundation
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Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1 beta and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.
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