Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 40, Issue 3, Pages 631-634Publisher
WILEY
DOI: 10.1002/eji.200940162
Keywords
Autoinflammatory; Cancer; Inflammasome; IL-1 inhibition; Liver
Categories
Funding
- Yorkshire Cancer Research
- NIHR-Leeds Musculoskeletal Biomedical Research Unit (LMBRU)
- The Royal Society
- FP7-HEALTH [2007-2.4.4-1]
- Charitable Foundation
- Arthritis Research Campaign (arc)
Ask authors/readers for more resources
A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin-associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available