Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 40, Issue 5, Pages 1486-1495Publisher
WILEY
DOI: 10.1002/eji.200939930
Keywords
DC; EAE; MAPK3; T-cell priming
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Funding
- Charite Rahel Hirsch Scholarship
- Deutsche Forschungsgemeinschaft (DFG) [SFB 650, SFB-TRR 43, Exc 257]
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DC are professional APC that instruct T cells during the inflammatory course of EAE. We have previously shown that MAPK3 (Erk1) is important for the induction of T-cell anergy. Our goal was to determine the influence of MAPK3 on the capacity of DC to arm T-cell responses in autoimmunity. We report that DC from Mapk3(-/-) mice have a significantly higher membrane expression of CD86 and MHC-II and - when loaded with the myelin oligodendrocyte glycoprotein - show a superior capacity to prime naive T cells towards an inflammatory phenotype than Mapk3(+/+) DC. Nonetheless and as previously described, Mapk3(-/-) mice were only slightly but not significantly more susceptible to myelin oligodendrocyte glycoprotein-induced EAE than WT littermate mice. However, Mapk3(+/+) mice engrafted with Mapk3(-/-) BM (KO -> WT) developed a severe form of EAE, in direct contrast to WT -> KO mice, which were even less sick than control WT -> WT mice. An infiltration of DC and accumulation of Th17 cells was also observed in the CNS of KO -> WT mice. Therefore, triggering of MAPK3 in the periphery might be a therapeutic option for the treatment of neuroinflammation since absence of this kinase in the immune system leads to severe EAE.
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