Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 40, Issue 8, Pages 2112-2118Publisher
WILEY
DOI: 10.1002/eji.201040562
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Lung DC bridge innate and adaptive immunity, and depending on the context, induce Th1, Th2 or Th17 response, to optimally clear infections. Conversely, lung DC can also prevent overt and harmful immune responses to harmless inhaled antigens via induction of Treg or via induction of neutralizing mucosal IgA antibodies. Here, we propose that these functions are not the result of a single population of DC, and instead, subsets of DC perform specialized functions.
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