Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 40, Issue 11, Pages 2969-2975Publisher
WILEY
DOI: 10.1002/eji.201040895
Keywords
Dendritic cells; Macrophages; Myeloid-derived suppressor cells; Neutrophils
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Funding
- NIH [CA84488, CA100062]
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Myeloid-derived suppressor cells (MDSC) play an important role in the cellular network regulating immune responses in cancer, chronic infectious diseases, autoimmunity, and in other pathological conditions. Morphological, phenotypic and functional heterogeneity is a hallmark of MDSC. This heterogeneity demonstrates the plasticity of this immune suppressive myeloid compartment, and shows how various tumors and infectious agents can have similar biological effects on myeloid cells despite the differences in the factors that they produce to influence the immune system; however, such a heterogeneity creates ambiguity in the definition of MDSC as well as confusion regarding the origin and fate of these cells. In this review, we will discuss recent findings that help to better clarify these issues and to determine the place of MDSC within the myeloid cell lineage.
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