Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 40, Issue 3, Pages 607-611Publisher
WILEY
DOI: 10.1002/eji.200940207
Keywords
Caspase-1; Danger signals; Necrosis
Categories
Funding
- National Institutes of Health [K08 AI065517, K08 AI067736]
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Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non-microbial insults causes the activation of nucleotide-binding domain leucine-rich repeat containing receptors in multiprotein complexes called inflammasomes. Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses.
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