Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 39, Issue 8, Pages 2040-2044Publisher
WILEY
DOI: 10.1002/eji.200939578
Keywords
Animal; Arthritis; Collagen; Model; Rheumatoid
Categories
Funding
- Medical Research Council, Arthritis Research Council (UK)
- Wellcome Trust
- BHF Intermediate Basic Science Research Fellowship [FS/08/035/25309]
- Medical Research Council [G9818261] Funding Source: researchfish
- MRC [G9818261] Funding Source: UKRI
Ask authors/readers for more resources
Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis. Despite the inherent limitations of all animal models, several rodent models have significantly progressed our understanding of the fundamental mechanisms underpinning rheumatoid arthritis and contributed to several current major advances in treatment. These models include the induced arthritis models such as collagen-induced arthritis, collagen-antibody-induced arthritis, zymosan-induced arthritis, and the methylated BSA model, and the genetically manipulated or spontaneous arthritis models such as the TNF-alpha-transgenic mouse, K/BxN mouse, and the Skg mouse. Here, we describe these animal models and discuss their advantages and limitations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available