Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 39, Issue 4, Pages 1046-1055Publisher
WILEY
DOI: 10.1002/eji.200838575
Keywords
Cytokines; Inflammation; Natural killer cells; Natural killer T cells; Th1/Th2 cells
Categories
Funding
- CNRS
- Universite de Paris Descartes
- Ligue Nationale contre le Cancer
- Chancellenie des Universites de Paris (Legs Poix)
- Ministere de l'Education Nationale de la Recherche et Technologie
- Vietnam government
Ask authors/readers for more resources
IL-33 has recently been identified as a cytokine endowed with pro-Th2 functions, raising the question of its effect on invariant natural killer T cell (iNKT), which are potent IL-4 producers. Here, we report a two-fold increase of iNKT-cell counts in spleen and liver after a 7-day treatment of mice with IL-33, which results from a direct effect, given that purified iNKT cells express the T1/ST2 receptor constitutively and respond to IL-33 by in vitro expansion and functional activation. Conversely to the expected pro-Th2 effect, IL-33 induced a preferential increase in IFN-gamma rather than IL-4 production upon TCR engagement that depended on endogenous IL-12. Moreover, in combination with the pro-inflammatory cytokine IL-12, IL-33 enhanced IFN-gamma production by both iNKT and NK cells. Taken together these data support the conclusion that IL-33 can contribute as a co-stimulatory factor to innate cellular immune responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available