Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 39, Issue 3, Pages 662-666Publisher
WILEY
DOI: 10.1002/eji.200839120
Keywords
gamma delta T cells; Autoimmunity; IL-17; Immunodeficiency; Infection
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Funding
- NIH [R01A144920, R01HL65410]
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IL-17 is produced not only by CD4(+) alpha beta T cells, but also CD8(+) alpha beta T cells, NKT cells, and gamma delta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, gamma delta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.
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