Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 39, Issue 6, Pages 1466-1471Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.200839040
Keywords
Human; Lymphoid organs; Mouse; Neuropilin-1; Treg
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Funding
- Ligue Nationale contre le Cancer (LNCC, France)
- Association pour la Recherche contre le Cancer (ARC, France)
- Fondation pour la Recherche Medicale (FRM, France)
- INCa (France)
- ANR (France)
- Canceropole (France)
- Fondation de France (France)
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Treg are immune cells that play a critical role in the regulation of the immune response. Although the transcription factor Foxp3 is widely accepted as the standard marker of Treg, specific surface markers are needed to better characterize these cells and decipher their mechanisms of action. Neuropilin-1 (Nrp-1), a membrane protein primarily involved in the nervous system, was identified as a specific marker of murine Treg, but its expression has not been rigorously investigated in human Treg. Here we show that in contrast to murine Treg and regardless of their origins (blood, thymus, spleen, lymph node or tonsil), human Foxp3(+) Treg do not specifically express Nrp-1. However, a population of Foxp3(-) Nrp-1(+) T cells can be detected in human secondary lymphoid organs, and Nrp-1 expression is induced on peripheral blood T lymphocytes upon in vitro activation. We conclude that Nrp-1 cannot be used as a specific marker of human Treg, but might represent a novel activation marker of human T cells both in vitro and in vivo.
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