4.5 Article

Human Th17 cells: Are they different from murine Th17 cells?

Journal

EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 39, Issue 3, Pages 637-640

Publisher

WILEY
DOI: 10.1002/eji.200839050

Keywords

Autoimmunity; Cytokines; Immune responses; NKT cells; Th cells

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Funding

  1. Italian Ministry of Education (40%)
  2. Italian Ministry of Health

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Type 17 Th (Th17) cells have been identified as a distinct population of CD4(+) effector T cells different from Th1 and Th2 ceUs. While the pre-eminent cytokine of Th17 cells is IFN-gamma and that of Th2 cells is IL-4, the distinctive cytokine of Th17 cells is IL-17A. However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects.

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