Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 38, Issue 12, Pages 3274-3281Publisher
WILEY
DOI: 10.1002/eji.200838950
Keywords
DC; Dectin-1; Th17; Treg
Categories
Funding
- Cancer Research UK
- University College London
- CRUK
- EMBO
Ask authors/readers for more resources
Th cells producing IL-17 play a pro-inflammatory role at mucosal surfaces. Treg at the same sites dampen inflammation and prevent immunopathology. Th cells producing IL-17 (Th17) and Treg are thought to be distinct populations defined by expression of the transcription factors ROR-gamma t and Foxp3, respectively. Here, we show that mouse CD25(+)Foxp3(+) Treg can be converted into a hybrid T-cell population characterized by the expression of Foxp3 and ROR-gamma t and the production of IL-17. Conversion was observed upon coculture with DC selectively activated via dectin-1, a C-type lectin receptor involved in fungal recognition, and depended on IL-23 produced by DC. Within the Foxp3(+) population, only Foxp3(+)ROR-gamma t(+) T cells but not Foxp3(+)ROR-gamma t(-)-T cells become Foxp3(+)IL-17(+) T cells. These results indicate that some Foxp3(+) T cells can produce IL-17 while retaining Foxp3 expression and suggest that Treg could play an unexpected pro-inflammatory role in some settings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available