Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 38, Issue 4, Pages 921-924Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.200738104
Keywords
Autoimmunity; Human; Regulatory T cell
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Funding
- National Institutes of Health [U19AI070352, P01AI39671]
- National Multiple Sclerosis Society [RG3825A1]
- 2004 Federation of Clinical Immunology Society Centers of Excellence Amgen Award
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CD4(+)CD25(+) regulatory T cells (Treg) appear to be critical in regulating immune responses to self-antigens. Treg deficiency is associated with several human autoimmune diseases. Although substantial progress has been made in the study of murine and human Treg, their fundamental mechanism of action remains unknown. In this review, we discuss the phenotype of human natural Treg, their functional mechanism, and their role in autoimmune disease.
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