Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 38, Issue 10, Pages 2697-2705Publisher
WILEY
DOI: 10.1002/eji.200838186
Keywords
Dendritic cell; IL-10; Malaria; Plasmodium vivax; Regulatory T cell
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Funding
- Fogarty International Center (FIC)
- National Institutes of Health (NIH)
- The Thailand Research Fund
- The Commission on Higher Education [CHE-RES-PD]
- BioMalPar
- FIC, NIH [D43-TW006571]
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Immunity induced by Plasmodium vivax infections leads to memory T-cell recruitment and activation during subsequent infections. Here, we investigated the role of regulatory T cells (Treg) in coordination with the host immune response during P. vivax infection. our results showed a significant increase in the percentage of FOXP3(+) Treg, IL-10-secreting Type I Treg (Tr1) and IL-10 levels in patients with acute P. vivax infection as compared with those found in either naive or immune controls. The concurrent increase in the Treg population could also be reproduced in vitro using peripheral blood mononuclear cells from naive controls stimulated with crude antigens extracted from P. vivax-infected red blood cells. Acute P. vivax infections were associated with a significant decrease in the numbers of DC, indicating a general immunosuppression during P. vivax infections. However, unlike P. falciparum infections, we found that the ratio of myeloid DC (MDC) to plasmacytoid. DC (PDC) was significantly lower in acute R vivax patients than that of naive and immune controls. Moreover, the reduction in PDC may be partly responsible for the poor antibody responses during P. vivax infections. Taken together, these results suggest that P. vivax parasites interact with DC, which alters the MDC/PDC ratio that potentially leads to Treg activation and IL-10 release.
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