Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 38, Issue 4, Pages 908-911Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/eji.200738114
Keywords
Cell surface molecules; Cytokines; Cytotoxicity; Mechanisms; Regulatory T cells
Categories
Funding
- National Institutes of Health (NIH)
- Juvenile Diabetes Research Foundation (JDRF)
- a Cancer Center Support CORE grant
- American Lebanese Syrian Associated Charities (ALSAC)
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A plethora of new regulatory T cell (Treg) mechanisms have recently emerged. This raises two important questions. First, how many molecules or mechanisms are required for Treg to work? Second, how should we evaluate the contribution of any given Treg molecule/mechanism and how is this likely to relate (or not) to the phenotype seen in Scurfy/Foxp3-deficient mice? In this discussion piece, I will briefly outline our current understanding of the Treg arsenal and address these important questions.
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