Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 38, Issue 9, Pages 2377-2385Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/eji.200838521
Keywords
dendritic cells; Langerhans cells; infectious diseases; HIV; herpesviruses
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Funding
- National Health and Medical Research Council of Australia
- Dutch Scientific Research [917-46-367, 912-04-025]
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Langerhans cells (LC) are a unique dendritic cell subset that are located in mucosal stratified squamous epithelium and skin epidermis. Their location is ideally suited for their function as antigen presenting cells that capture invading viruses and induce anti-viral immunity. However, it is becoming evident that the interaction between LC and viruses can result in different responses, depending on the virus and the receptors involved. Here we will discuss the recent data on the similarities and differences in roles of LC in viral immunity to and infection with HIV, herpes simplex and varicella-zoster virus. Although all three viruses interact with LC during initial infection, the effects can be quite different, reflecting differences in biology and pathogenesis.
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