Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 38, Issue 11, Pages 2930-2933Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.200838755
Keywords
Arming; Education; Licensing; NK cells; Tolerance
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Funding
- Oncosuisse
- Swiss National Science Foundation
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NK cells can kill transformed, infected and stressed cells while most normal cells are spared. NK cells are activated by various endogenous self-ligands, some of which are actually expressed by normal cells. Thus, NK cells are inherently self-reactive and consequently, potentially auto-aggressive. How these cells are prevented from attacking normal cells while ensuring reactivity to diseased cells is a major unresolved question for NK-cell biologists.
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