Journal
EUROPEAN JOURNAL OF HUMAN GENETICS
Volume 20, Issue 4, Pages 376-380Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ejhg.2011.208
Keywords
preimplantation genetic diagnosis; PGD; reciprocal translocations; reproductive counseling
Funding
- University Hospital UZ Brussel VUB
- University Research Council
- FWO Vlaanderen
- Willy Gepts Foundation
- EU
- Bertarelli Foundation
- Shering-Plough International and Belgium
- Merck Sharp and Dohme Belgium
- IBSA
- Ferring International
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Carriers of reciprocal translocations (rcp) are known to be at risk for reproductive difficulties. Preimplantation genetic diagnosis (PGD) is one of the options these carriers have to try in order to fulfil their desire to have a child. In the present study, we retrospectively looked at the results of 11 years (1997-2007) of PGD for rcp in our center to improve the reproductive counseling of these carriers. During this period 312 cycles were performed for 69 male and 73 female carriers. The mean female age was 32.8 years, the mean male age 35.8 years. Most carriers were diagnosed with a translocation because of fertility problems or recurrent miscarriages, and most of them opted for PGD to avoid these problems. In 150 of the 312 cycles, embryo transfer (ET) was feasible and 40 women had a successful singleton or twin pregnancy. This gives a live birth delivery rate of 12.8% per started cycle and of 26.7% per cycle with ET. Owing to the large number of abnormal embryos, PGD cycles for rcp often lead to cancellation of ET, explaining the low success rate when expressed per cycle with oocyte pick-up. Once ET was feasible, the live birth delivery rate was similar to that of PGD in general at our center. PGD is therefore an established option for specific reciprocal translocation carriers. European Journal of Human Genetics (2012) 20, 376-380; doi: 10.1038/ejhg.2011.208; published online 9 November 2011
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