Journal
EUROPEAN JOURNAL OF HUMAN GENETICS
Volume 19, Issue 1, Pages 84-88Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ejhg.2010.141
Keywords
population genetics; Africa; population history
Funding
- Direccion General de Investigacion, Ministerio de Ciencia y Tecnologia, Spain [SAF2007-63171, BFU2007-63657]
- Direccio General de Recerca, Generalitat de Catalunya [2009 SGR 1101]
- Programa de becas FPU del Ministerio de Educacion y Ciencia, Spain [AP2005-3982]
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Studies of large sets of single nucleotide polymorphism (SNP) data have proven to be a powerful tool in the analysis of the genetic structure of human populations. In this work, we analyze genotyping data for 2841 SNPs in 12 sub-Saharan African populations, including a previously unsampled region of southeastern Africa (Mozambique). We show that robust results in a world-wide perspective can be obtained when analyzing only 1000 SNPs. Our main results both confirm the results of previous studies, and show new and interesting features in sub-Saharan African genetic complexity. There is a strong differentiation of Nilo-Saharans, much beyond what would be expected by geography. Hunter-gatherer populations (Khoisan and Pygmies) show a clear distinctiveness with very intrinsic Pygmy (and not only Khoisan) genetic features. Populations of the West Africa present an unexpected similarity among them, possibly the result of a population expansion. Finally, we find a strong differentiation of the southeastern Bantu population from Mozambique, which suggests an assimilation of a pre-Bantu substrate by Bantu speakers in the region. European Journal of Human Genetics (2011) 19, 84-88; doi:10.1038/ejhg.2010.141; published online 25 August 2010
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