Journal
EUROPEAN JOURNAL OF HISTOCHEMISTRY
Volume 58, Issue 1, Pages 62-64Publisher
PAGEPRESS PUBL
DOI: 10.4081/ejh.2014.2358
Keywords
cell nucleus; cerebral cavernous malformations; KRIT1; transcription; electron microscopy; immunocytochemistry
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KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell lines, revealing its unexpected localization on actively transcribing nuclear domains such as the perichromatin fibrils and the nucleolar dense fibrillar component. These preliminary data indicate a still undescribed and unknown role for KRIT1 inside the nucleus.
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