Journal
ACS NANO
Volume 9, Issue 3, Pages 3060-3074Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn5072792
Keywords
quantum dot barcode; smartphone; point-of-care; infectious disease; diagnostics; wireless; nanoparticle
Categories
Funding
- Collaborative Health Research Program [CHRPJ-398432, CPG-112321]
- Canadian Institute of Health Research [MOP-93532]
- Natural Sciences and Engineering Research Council [SMFSU 459456-13, RGPIN-288231]
- Ontario Ministry of Research and Innovation
- Canadian Foundation for Innovation
- Ontario Graduate Scholarship
- Natural Sciences and Engineering Research Council Canada Graduate Scholarship
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Inorganic natiOpatticles are ideal precursors for engineering barcodes for rapidly detecting diseases. Despite advances in the chemical design of these barcodes, they have not advanced to clinical use because they lack sensitivity and are not cost-effective due to requirement of a large read-out system. Here we combined recent advances in quantum dot 'barcode technology with smattphones and isothermal amplification to engineer a simple and low-cost chip-based wireless multiplex diagnostic device. We characterized the analytical peittfinance of this device and demonstrated that the deviceis capable of detecting down to 1000 viral genetic copies per milliliter, and this enabled the diagnosis of patients infected with HIV or hepatitis B. More importantly, the barcoding enabled us to detect multiple infectious pathogens simultaneously, in a-single test, in less than 1 h. This multiplexing capability of the device enables the diagnosis of infections that are difficult to differentiate clinically due to common symptoms such as a fever or rash. The integration of quantum dot barcoding technology with a smattphone-reader provides a capacity for global surveillance of infectious diseases and the potential to accelerate knowledge exchange transfer of emerging or exigent disease threats with healthcare and military organizations in real time.
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