Journal
EUROPEAN JOURNAL OF HEART FAILURE
Volume 10, Issue 7, Pages 646-651Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejheart.2008.05.008
Keywords
extracellular superoxide dismutase; uric acid; endothelial function; chronic heart failure; oxidative stress
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increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This paradoxical relationship between uric acid and endothelial function in chronic heart failure patients remains poorly understood. Thirty-eight chronic heart failure patients (New York Heart Association functional class II-III, mean age 58 +/- 10 years and mean left ventricular ejection fraction 25 +/- 8%) and twelve age-and-sex-inatched healthy controls were studied. Chronic heart failure patients showed higher uric acid levels (7.3 +/- 2.3 mg/dL vs. 6.1 +/- 0.2 mg/dL p < 0.05) and lower extracellular superoxide dismutase activity (136 +/- 36 U ml(-1) min(-1) vs. 203 +/- 61 U ml(-1) min(-1), p < 0.01) and endothelium-dependent vasodilatation(4.0 +/- 1.6%v. 9.1 +/- 3.0%,p < 0.01) when compared with control subjects. In chronic heart failure patients, correlations between both uric acid levels and extracellular superoxide dismutase activity (r-0.45; p < 0.01), and uric acid and endothelium-dependent vasodilatation (r=0.35; p=0.03) were detected. These correlations were not observed in healthy individuals, suggesting a positive effect of uric acid on endothelial function partially mediated by modulation of extracellular superoxide dismutase activity in chronic heart failure. (c) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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