Journal
EUROPEAN JOURNAL OF HAEMATOLOGY
Volume 101, Issue 6, Pages 721-727Publisher
WILEY
DOI: 10.1111/ejh.13162
Keywords
acute leukemia; antibiotic prophylaxis; febrile neutropenia; pediatrics
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Antibiotics are frequently administered for prophylaxis of fever in neutropenic children with cancer. This strategy is mainly derived from adults' data, and various pediatric studies evidenced the effectiveness of antibiotics (eg, fluoroquinolones) in the prevention of febrile neutropenia. However, only two pediatric randomized, double-blind, placebo-controlled trials have been performed, with a total of 262 leukemic children enrolled, and no other one was ever powered for analyzing effectiveness over other infectious complications. In an era of increasing antibiotic resistance, the widespread use of antibiotic prophylaxis in neutropenic leukemic children needs to be strongly supported.
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