Journal
EUROPEAN JOURNAL OF HAEMATOLOGY
Volume 93, Issue 1, Pages 9-18Publisher
WILEY
DOI: 10.1111/ejh.12285
Keywords
diffuse large B cell lymphoma; elderly; cachexia; adipopenia; fat tissue loss; prognosis
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Objectives Approximately 30% of DLBCL patients are older than 70yr. This study evaluated the prognostic impact of a cachexia score (CS) including fat tissue loss (adipopenia) and sarcopenia as assessed by computed tomography (CT scan) in elderly DLBCL patients treated with chemotherapy and rituximab (R). Methods This retrospective analysis included 80 DLBCL patients older than 70yr treated with R-CHOP or R-miniCHOP. Skeletal muscle (SM) and visceral (V) and subcutaneous (S) adipose (A) tissues were measured by analysing CT images at the third lumbar (L3) level. Results The median age of the patients was 78yr. Forty-four and 46 patients were considered sarcopenic and adipopenic, respectively. The median progression-free survival (PFS) was 13.6months in the adipopenic group and 49.4months in the non-adipopenic group [hazard ratio (HR)=2.27; 95% confidence interval (CI): 1.3-4; P=0.0042]. The median overall survival (OS) was 25.7months in the adipopenic group and 57.1months in the non-adipopenic group (HR=1.93; 95% CI: 1.05-3.55; P=0.0342). A two-point CS including adipopenia and sarcopenia was created and defined two distinct risk groups with differences in outcomes that were highly significant. The CS was predictive of the prognosis in a multivariate analysis including body mass index (BMI) (< or 25kg/m2), age (< or 80yr), international prognostic index (IPI) and albuminaemia (HR=3.67; 95% CI=1.93-6.97; P<0.0001). Conclusion A CS including sarcopenia and adipopenia, assessed by a single CT scan slice, predicts outcome independent of BMI and the IPI.
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