Journal
EUROPEAN JOURNAL OF HAEMATOLOGY
Volume 92, Issue 1, Pages 83-87Publisher
WILEY-BLACKWELL
DOI: 10.1111/ejh.12208
Keywords
progressive multifocal leukoencephalopathy; hematopoietic cell transplantation; allogeneic bone marrow transplantation; immunocompromised host; encephalitis
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Progressive multifocal leukoencephalopathy (PML), a demyelinating disorder caused by brain infection with JC virus, is a neurological complication of immunocompromised states and immunosuppressive therapies. While most commonly seen in the HIV/AIDS population, patients with hematologic malignancies are also at risk following treatment protocols including monoclonal antibodies such as rituximab and after hematopoietic stem cell transplantation. Here, we present the case of PML following allogeneic HCT that highlights potential diagnostic difficulties. We also review the literature regarding PML following HCT and described therapies employed to attempt to treat this disorder.
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