Journal
EUROPEAN JOURNAL OF EPIDEMIOLOGY
Volume 26, Issue 2, Pages 135-144Publisher
SPRINGER
DOI: 10.1007/s10654-010-9526-5
Keywords
Inflammation; Pulmonary function; Cohort study; Epidemiology
Categories
Funding
- Medical Research Council
- Economic and Social Research Council
- British Heart Foundation
- Health and Safety Executive
- Department of Health
- National Heart Lung and Blood Institute, US, NIH [HL36310]
- National Institute on Aging, US, NIH [AG13196]
- Agency for Health Care Policy Research [HS06516]
- John D and Catherine T MacArthur Foundation Research Network on Successful Mid life Development and Socioeconomic Status and Health
- NIA [AG13196]
- MRC [G8802774]
- Academy of Finland [105195, 117604]
- AGENCY FOR HEALTHCARE RESEARCH AND QUALITY [R01HS006516] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL036310] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG013196, R37AG013196] Funding Source: NIH RePORTER
- MRC [G0902037] Funding Source: UKRI
- British Heart Foundation [RG/07/008/23674] Funding Source: researchfish
- Medical Research Council [G0100222, G19/35, G8802774, G0902037] Funding Source: researchfish
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To assess whether two inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and change in their concentrations over 12 years, are associated with lung function (FVC and FEV(1)) 12 years after baseline. Data are from over 1,500 participants free from self-reported respiratory problems in a large-scale prospective cohort study of white-collar male and female civil servants. CRP and IL-6 measured at baseline (1991-1993) and follow-up (2002-2004) and FVC and FEV(1), measured at follow-up. Results adjusted for sociodemographic and anthropometric characteristics, health behaviours, biological factors, chronic conditions and medications, and corrected for short-term variability in CRP and IL-6 concentrations. Higher baseline levels of CRP and IL-6 were strongly associated with lower FVC and FEV(1), independent of potential confounders. A 10% increase serum CRP from baseline to follow-up was associated with lower values of FVC and FEV(1) at follow-up, 4.7 and 3.0 ml, respectively. The corresponding values for a 10% increase in IL-6 were 12.6 ml for FVC and 7.3 ml for FEV(1). Systemic low-grade inflammation is associated with only slightly poorer pulmonary function in a population free from self-reported respiratory problems 12 years earlier. These data provide evidence linking inflammation to adverse outcomes beyond cardiovascular disease. Interventions targeting inflammation may prevent lung function impairment.
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