Journal
EUROPEAN JOURNAL OF EPIDEMIOLOGY
Volume 25, Issue 8, Pages 561-568Publisher
SPRINGER
DOI: 10.1007/s10654-010-9476-y
Keywords
Cognition; Executive function; Metabolic syndrome; Insulin-resistance; Adiponectin
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Funding
- Netherlands Organization for Scientific Research (NWO)
- Nutri-genomics Consortium (NGC)
- Centre for Medical Systems Biology (CMSB)
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While type 2 diabetes is well-known to be associated with poorer cognitive performance, few studies have reported on the association of metabolic syndrome (MetS) and contributing factors, such as insulin-resistance (HOMA-IR), low adiponectin-, and high C-reactive protein (CRP)- levels. We studied whether these factors are related to cognitive function and which of the MetS components are independently associated. The study was embedded in an ongoing family-based cohort study in a Dutch population. All participants underwent physical examinations, biomedical measurements, and neuropsychological testing. Linear regression models were used to determine the association between MetS, HOMA-IR, adiponectin levels, CRP, and cognitive test scores. Cross-sectional analyses were performed in 1,898 subjects (mean age 48 years, 43% men). People with MetS had significantly higher HOMA-IR scores, lower adiponectin levels, and higher CRP levels. MetS and high HOMA-IR were associated with poorer executive function in women (P = 0.03 and P = 0.009). MetS and HOMA-IR are associated with poorer executive function in women.
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