Journal
EUROPEAN JOURNAL OF ENDOCRINOLOGY
Volume 164, Issue 5, Pages 751-758Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/EJE-10-1074
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Funding
- Instand e.V.
- Federal Ministry of Education and Research
- Ministry of Cultural Affairs
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH)
- German Federal Ministry of Education, Science, Research, and Technology
- State of Bavaria
- Else Kroner Fresenius Stiftung
- German Research Organization [Re 752/17-1]
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Objective: The aim of this study was to analyze the potential association of the plasma aldosterone concentration (PAC) with the metabolic syndrome (MetS) and its components in two German population-based studies. Methods: We selected 2830 and 2901 participants (31-80 years) from the follow-ups of the Study of Health in Pomerania (SHIP)-1 and the Cooperative Health Research in the Region of Augsburg (KORA) F4 respectively. MetS was defined as the presence of at least three out of the following five criteria: waist circumference >= 94 cm (men (m)) and >= 80 cm (women (w)); high-density lipoprotein (HDL) cholesterol <1.0 mmol/l (m) and <1.3 mmol/l (w); blood pressure >= 130/85 mmHg or antihypertensive treatment; non-fasting glucose (SHIP-1) >= 8 mmol/l, fasting glucose (KORA F4) >= 5.55 mmol/l or antidiabetic treatment; non-fasting triglycerides (SHIP-1) >= 2.3 mmol/l, fasting triglycerides (KORA F4) >= 1.7 mmol/l, or lipid-lowering treatment. We calculated logistic regression models by comparing the highest study-and sex-specific PAC quintiles versus all lower quintiles. Results: MetS was common with 48.1% (m) and 34.8% (w) in SHIP-1 and 42.7% (m) and 27.5% (w) in KORA F4. Our logistic regression models revealed associations of PAC with MetS, elevated triglycerides, and decreased HDL cholesterol in SHIP-1 and KORA F4. Conclusions: Our findings add to the increasing evidence supporting a relation between aldosterone and MetS and suggest that aldosterone may be involved in the pathophysiology of MetS and lipid metabolism disorders.
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