Journal
EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY
Volume 12, Issue 4, Pages 278-282Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ejechocard/jeq193
Keywords
Left atrial remodelling; RAS inhibitor; Atrial fibrillation
Categories
Ask authors/readers for more resources
Aims Left atrium (LA) gradually enlarges with the time course of atrial fibrillation (AF). The aim of this study was to examine whether the renin-angiotensin system (RAS) inhibitor could prevent LA remodelling in patients with chronic AF. Methods and results Forty-one patients with chronic non-valvular AF were enrolled and divided into the following two groups: the RAS group taking an RAS inhibitor and the non-RAS group not taking it. We compared echocardiographic parameters including LA volume at the beginning and the end of follow-up. Percent change of these parameters was calculated from the value at the end of follow-up divided by the value at the beginning of follow-up. An enlargement of LA volume index and a decrease in LA expansion fraction was significantly prevented in the RAS group. Administration of RAS inhibitors was significantly associated with the prevention of increasing LA volume in multivariate analysis. Conclusion RAS inhibitors may prevent structural and functional degradation of LA in chronic non-valvular AF.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available