Journal
EUROPEAN JOURNAL OF CLINICAL NUTRITION
Volume 66, Issue 10, Pages 1082-1092Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ejcn.2012.85
Keywords
fruit; vegetables; type 2 diabetes mellitus; epidemiology; meta-analysis; review
Categories
Funding
- EU FP6 programme [LSHM_CT_2006_037197]
- NL Agency [IGE05012]
- Incentive Grant from the Board of the UMC Utrecht
- Swedish Research Council
- Novo Nordisk
- Swedish Diabetes Association
- Swedish Heart-Lung Foundation
- German Cancer Aid
- Cancer Research UK
- Health Research Fund (FIS) of the Spanish Ministry of Health
- Murcia Regional Government [6236]
- Danish Cancer Society
- Compagnia di San Paolo
- Asturias Regional Government
- Vasterboten County Council
- UMC Utrecht
- Dutch Ministry of Public Health, Welfare and Sports
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands
- AIRE-ONLUS Ragusa
- AVIS-Ragusa
- Sicilian Regional Government
- Imperial College Biomedical Research Centre
- Medical Research Council [MC_U106179471, MC_UP_A100_1003] Funding Source: researchfish
- MRC [MC_UP_A100_1003] Funding Source: UKRI
Ask authors/readers for more resources
Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available