A synthesis of functionalized spiro isobenzofuran-1,6′-[1,3] thiazines from phthalic anhydride-malononitrile adduct and ammonium carbamodithioates

The reaction of 2-[3-oxo-isobenzofuran-1(3H)-ylidene]malononitrile, generated from phthalic anhydride and malononitrile, with ammonium alky(aryl)carbamodithioates, leading to the formation of functionalized spiro isobenzofuran-1,6'-[1,3] thiazine systems, in good yields, is reported. [GRAPHICS] Highlights The reaction of 2-[3-oxo-isobenzofuran-1(3H)-ylidene]malononi trile, with ammonium alky(aryl)carbamodithioates, leads to the formation of functionalized spiro isobenzofuran-1,6'-[1,3]thiazine systems, in good yields.