Journal
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Volume 43, Issue 3, Pages 286-291Publisher
WILEY-BLACKWELL
DOI: 10.1111/eci.12043
Keywords
Breast cancer; cell death; docetaxel; epirubicin; HMGB1; predictive marker
Funding
- OeNB [13220]
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Background The response of breast cancer patients to neoadjuvant chemotherapy (NCT) is highly heterogeneous, and reliable predictive instruments remain to be defined. High-mobility group box-1 (HMGB-1) protein is a cell death marker, which is easily detectable in plasma. We hypothesized that the initial dose of NCT with epirubicin/docetaxel induces changes in plasma HMGB-1 which could allow for an early prediction of response to therapy. Materials and methods First, we analysed whether epirubicin/docetaxel releases HMGB-1 from HCC1143 breast cancer cells in vitro. Thereafter, plasma HMGB-1 levels before and 14days after the first dose of epirubicin/docetaxel-based NCT were determined in 41 breast cancer patients and correlated with pathological response to treatment. Results Treatment of HCC1143 cells with epirubicin/docetaxel resulted in a significant HMGB-1 release in vitro. In vivo, HMGB-1 levels increased significantly only in responders (pathological complete response or partial remission, n=22) but not in nonresponders (stable or progressive disease, n=19). Conclusion Our data suggest that early dynamic changes of plasma HMGB1 could be a promising biomarker to predict the final response to NCT in breast cancer patients.
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