Journal
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Volume 39, Issue 10, Pages 866-875Publisher
WILEY
DOI: 10.1111/j.1365-2362.2009.02192.x
Keywords
Arteriogenesis; collateral circulation; coronary artery disease; external counterpulsation
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P>Background Arteriogenesis (collateral artery growth) is nature's most efficient rescue mechanism to overcome the fatal consequences of arterial occlusion or stenosis. The goal of this trial was to investigate the effect of external counterpulsation (ECP) on coronary collateral artery growth. Materials and methods A total of 23 patients (age 61 +/- 2 center dot 5 years) with stable coronary artery disease and at least one haemodynamic significant stenosis eligible for percutaneous coronary intervention were prospectively recruited into the two study groups in a 2 : 1 manner (ECP : control). One group (ECP group, n = 16) underwent 35 1-h sessions of ECP in 7 weeks. In the control group (n = 7), the natural course of collateral circulation over 7 weeks was evaluated. All patients underwent a cardiac catheterization at baseline and after 7 weeks, with invasive measurements of the pressure-derived collateral flow index (CFIp, primary endpoint) and fractional flow reserve (FFR). Results In the ECP group, the CFIp (from 0 center dot 08 +/- 0 center dot 01 to 0 center dot 15 +/- 0 center dot 02; P < 0 center dot 001) and FFR (from 0 center dot 68 +/- 0 center dot 03 to 0 center dot 79 +/- 0 center dot 03; P = 0 center dot 001) improved significantly, while in the control group no change was observed. Only the ECP group showed a reduction of the Canadian Cardiovascular Society (CCS, P = 0 center dot 008) and New York Heart Association (NYHA, P < 0 center dot 001) classification. Conclusion In this study, we provide direct functional evidence for the stimulation of coronary arteriogenesis via ECP in patients with stable coronary artery disease. These data might open a novel noninvasive and preventive treatment avenue for patients with non-acute vascular stenotic disease.
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