Journal
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Volume 38, Issue 7, Pages 457-461Publisher
WILEY
DOI: 10.1111/j.1365-2362.2008.01968.x
Keywords
AKT activation; erythropoietin (EPO); nitric oxide; vascular protection
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The major physiological function of erythropoietin (EPO) is thought to be the induction of erythropoiesis. However, a growing body of evidence indicates that EPO as well as recombinant human erythropoietin (rHuEPO) and its analogues have tissue-protective effects and prevent tissue damage during ischaemia. This mini review summarizes the present knowledge on protective vascular effects of EPO and discusses the potential underlying mechanisms.
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