Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 93, Issue 4, Pages 170-177Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2014.03.001
Keywords
Adipogenesis; Adipocyte differentiation; Transcriptional regulation; HAT; HDAC
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Funding
- National Natural Science Foundation of China [31272457]
- Hubei Provincial Creative Team Project of Agricultural Science and Technology [2007-620]
- Fundamental Research Funds for the Central Universities [2012MBDX010, 2013PY047]
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Adipogenesis is a complex process strictly regulated by a well-established cascade that has been thoroughly studied in the last two decades. This process is governed by complex regulatory networks that involve the activation/inhibition of multiple functional genes, and is controlled by histone-modifying enzymes. Among such modification enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs) play important roles in the transcriptional regulation and post-translational modification of protein acetylation. HATs and HDACs have been shown to respond to signals that regulate cell differentiation, participate in the regulation of protein acetylation, mediate transcription and post-translation modifications, and directly acetylate/deacetylate various transcription factors and regulatory proteins. In this paper, we review the role of HATs and HDACs in white and brown adipocyte differentiation and adipogenesis, to expand our knowledge on fat formation and adipose tissue biology. (C) 2014 Elsevier GmbH. All rights reserved.
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