Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 91, Issue 2, Pages 107-117Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2011.09.013
Keywords
Protein acyltransferases; DHHC/ZDHHC; Membrane localization; Protein palmitoylation
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Funding
- Polish Ministry of Science and Higher Education [N.N.301 1611435]
- Office of the Marshal of the Lubuskie Voivodeship
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Palmitoylation is one of the most common posttranslational lipid modifications of proteins and we now know quite a lot about it. However, the state of knowledge about the enzymes that catalyze this process is clearly insufficient. This review is focused on 23 human DHHC genes and their products - protein palmitoyltransferases. Here we describe mainly the structure and function of these proteins, but also, to a lesser degree, what the substrates of the enzymes are and whether they are related to various diseases. The main aim of this review was to catalogue existing information concerning the human DHHC family of genes/proteins, making them and their functions easier to understand. (C) 2011 Elsevier GmbH. All rights reserved.
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