Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 89, Issue 12, Pages 888-894Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2010.06.013
Keywords
Membrane lipids; Phospholipid biosynthesis; Phosphatidylethanolamine; Phosphatidylcholine; Phospholipid N-methyltransferase; Phosphatidylcholine synthase; Symbiotic; Pathogenic; Plant microbe-interaction; Choline; S-Adenosylmethionine; S-Adenosylhomocysteine
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Funding
- German Research Foundation (DFG) [SFB 480, NA 240/7-1]
- Promotionskolleg of the Ruhr-University Bochum
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Phosphatidylcholine (PC), a typical eukaryotic membrane phospholipid, is present in only about 10% of all bacterial species, in particular in bacteria interacting with eukaryotes. A number of studies revealed that PC plays a fundamental role in symbiotic and pathogenic microbe-host interactions. Agrobacterium tumefaciens mutants lacking PC are unable to elicit plant tumors. The human pathogens Brucella abortus and Legionella pneumophila require PC for full virulence. The plant symbionts Bradyrhizobium japonicum and Sinorhizobium meliloti depend on wild-type levels of PC to establish an efficient root nodule symbiosis. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (Pcs) pathway. The methylation pathway involves a three-step methylation of phosphatidylethanolamine by at least one phospholipid N-methyltransferase to yield phosphatidylcholine. In the Pcs pathway, choline is condensed directly with CDP-diacylglycerol to form PC. This review focuses on the biosynthetic pathways and the significance of PC in bacteria with an emphasis on plant-microbe interactions. (C) 2010 Elsevier GmbH. All rights reserved.
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