Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 89, Issue 1, Pages 63-75Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ejcb.2009.10.013
Keywords
sugar nucleotides NDP-sugars; nucleoside triphosphates; glycophosphotransferases; cycloSal-approach; bioconjugates
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Funding
- Deutsche Forschungsgemeinschaft
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In this review, we summarize results obtained using a conceptionally new chemical synthesis of NDP-sugars based on cycloSaligenyl (cycloSal) nucleotides as starting material (cycloSal technique). The cycloSal technique not only leads to stereoisomerically defined NDP-sugars in high yield, but the same principle provides very efficient routes towards nucleoside di- and -triphosphates. Moreover, sugar-nucleotides such as CMP-Neu5Ac and dinucleoside polyphosphates are available. Thus, the method offers a nearly universal chemical access towards a large number of highly interesting bioconjugates and biomolecules. (C) 2009 Elsevier GmbH. All rights reserved.
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