Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 89, Issue 5, Pages 394-401Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2009.10.020
Keywords
Actin polymerization; Profilin; mRNA localization; FISH; Microtubules
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Funding
- Carl Trygger Foundation
- Cancer and Allergy Association
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Specific localization of messenger RNA (mRNA) appears to be a general mechanism to accumulate certain proteins to subcellular compartments for participation in local processes, thereby maintaining cell polarity under strict spatiotemporal control. Transportation of mRNA with associated protein components (RNP granules) by the actin microfilament or the microtubule systems is one important mechanism to achieve this locally distributed protein production. Here we provide evidence for a microtubule-dependent localization of mRNA encoding the actin regulatory protein profilin to sites in mouse embryonic fibroblasts, which express enhanced actin polymerization. (c) 2010 Elsevier GmbH. All rights reserved.
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