Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 87, Issue 8-9, Pages 649-667Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ejcb.2008.04.001
Keywords
actin cytoskeleton; cofilin; ADF; LIM kinase; slingshot; cell migration; cancer; cell invasion; Rho GTPases; PIP2; phospholipase C
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Funding
- FWO [G.O157.05]
- BOF [D1J04806]
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The actin-binding proteins of the actin-depolymerisation factor (ADF)/cofilin family were first described more than three decades ago, but research on these proteins still occupies a front role in the actin and cell migration field. Moreover, cofilin activity is implicated in the malignant, invasive properties of cancer cells. The effects of ADF/cofilins on actin dynamics are diverse and their regulation is complex. In stimulated cells, multiple signalling pathways can be initiated resulting in different activation/deactivation switches that control ADF/cofilin activity. The output of this entire regulatory system, in combination with spatial and temporal segregation of the activation mechanisms, underlies the contribution of ADF/cofilins to various cell migration/invasion phenotypes. In this framework, we describe Current views on how ADF/cofilins function in migrating and invading cells. (C) 2008 Elsevier GmbH. All rights reserved.
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