Journal
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
Volume 39, Issue 1, Pages 44-48Publisher
OXFORD UNIV PRESS INC
DOI: 10.1016/j.ejcts.2010.06.007
Keywords
CABG; Platelet-rich plasma; Wound infection
Funding
- Biomet Biologics, Inc
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Objective: Wound infection is still a common problem after open long saphenous vein harvesting. Platelets are important for the healing process. The hypothesis was that spraying of the wounds with platelet-rich plasma might reduce the frequency of harvest site infections. Methods: From January to October 2008, 140 patients undergoing first-time coronary artery bypass grafting were randomized into two groups of 70 patients. Both groups had standard surgical leg wound closure and care except topical application of platelet-rich plasma as adjunctive treatment in the active treatment group. End points were wound infection and cosmetic result at 6 weeks. Results: The follow-up was 100% complete. Nine patients (13%) in the treatment group and eight (11%) in the control group experienced harvest site infection (p = 0.80). The overall cosmetic result was also similar between the groups (p = 0.34), but the top score was borderline and more frequent in the treatment group (p = 0.050). Conclusion: Topical application of autologous platelet-rich plasma on vein harvest wounds did not reduce the rate of surgical site infection. (C) 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
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