Journal
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
Volume 41, Issue 5, Pages 1063-1067Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ejcts/ezr170
Keywords
Cardiopulmonary exercise; Pectus excavatum; Musculoskeletal disease; Lung function; Stroke index
Funding
- Aarhus University Research Council
- Director Kurt Bonnelycke and his wife Grethe Bonnelycke's Foundation
- Grosserer L. F. Foght's Foundation
- Aase and Ejnar Danielsen's Foundation
- Helga and Peter Korning Foundation
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Patients with pectus excavatum have compromised cardiac function during exercise. We hypothesized that the Nuss technique would improve cardiopulmonary function during exercise. We investigated 75 teenagers (49 patients and 26 controls) at rest and during bicycle exercise prior to surgery and 1 year postoperative. Prior to surgery, patients had a lower cardiac index 6.6 +/- 1.1 l/min/m(2) when compared with controls 8.1 +/- 1.0 l/min/m(2) during submaximal exercise, P = 0.0001. There was no difference in heart rate or increase in heart rate between the two groups. One year after surgery, cardiac index had significantly increased in the pectus group, P = 0.0054 although cardiac index was still significantly lower 7.2 +/- 1.0 l/min/m(2) when compared with the control subjects (8.5 +/- 1.6 l/min/m(2), P = 0.0008). Both the patients and the controls increased their VO2 max during the one-year study period although the controls increased most. Right ventricular diastolic dimension increased in both groups over the one-year study period and left ventricular dimensions increased in the patients. Before operation, the patients had lower forced expiratory capacity FEV1 86 +/- 13% when compared with controls 94 +/- 10%, P = 0.009. Patients increased FEV1/forced vital capacity over the one-year long study course although there were no differences between groups. Patients with pectus excavatum have lower cardiac index at submaximal exercise when compared with healthy age-matched controls. Their cardiac index and FEV1 are increased one year after the modified Nuss operation.
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