Association of IL6 and IL10 with renal dysfunction and the use of haemofiltration during cardiopulmonary bypass

Objective: Assessment of the effects of haemofiltration during cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CABG) on the renal function and correlation with interleukin 6 (IL6) and interleukin 10 (IL10) levels. Methods: Seventy-nine patients scheduled for elective CABG were prospectively randomised into two groups. Group A with a haemofilter attached to arterial line of the CPB circuit and group B without a haemofilter. The two groups were comparable in their symptoms, sex, and previous history of myocardial infarction, left ventricular function, cross-clamp time, bypass time and total grafting per patients. Blood urea and creatinine Levels were measured the day before operation, 12 h after operation and on the 3rd postoperative day. IL6 and IL10 were measured in blood samples collected 1 h before surgery, on arrival to ITU and after 12 h. IL6 and IL-10 levels were measured using ELISA test. Results: High levels of IL6 (>100 pg/ml) postoperatively were associated with increased incidence of renal dysfunction (p < 0.017). Additionally, high IL10 (>30 pg/ml) levels postoperatively were associated with increased incidence of renal dysfunction (p, < 0.014). There were no effects of the haemofilter on postoperative IL6 and IL10 levels. Use of haemofiltration during CPB was found not to be protective against renal dysfunction (p < 0.071). Conclusions: Haemofilter use during cardiopulmonary bypass does not have a protective effect on postoperative kidney function. Haemofilter has no effect on the level of IL6 and IL10. (C) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.