Long-term outcome of thoracoscopic extended thymectomy for nonthymomatous myasthenia gravis

Background: Thoracoscopic thymectomy has shown promise in the integrated management of myasthenia gravis (MG) although there is still scant data on tong-term results. The aim of this study was to analyze tong-term (>5 years) results of thoracoscopic extended thymectomy in nonthymomatous MG. Methods: We retrospectively reviewed 32 patients operated on between 1995 and 2003. MG foundation of America clinical classification (MGFA), symptoms' duration, preoperative crisis, anticholinesterase-drugs dosage, steroid use, and acetylcholine receptor antibodies were evaluated in ail patients with annual follow-up. Anti-MuSK antibody titer was also assessed at the last follow-up. Results: There were 21 females and 11 mates with a median age of 36 years. Ten patients were seronegative for acetylcholine receptor antibodies. Patients in MGFA class I, II, III and IV were 7 (22%), 15 (44%), 9 (28%), 2 (6%) patients, respectively. Median symptoms duration was 11 months. There was no mortality or major morbidity. Median hospital stay was 4.0 days. Ectopic thymic tissue was found in 18 (56%) patients. Median follow-up was 119 months (range 60-156 months). There was no residual thoracic pain. Estimated 10-year remission rate was 50%. At 72 months, 27 (84.3%) patients were improved or in complete remission. At the univariate analysis, shorter duration of symptoms (<12 months) and absence of oropharyngeal involvement were both predictors of response to thymectomy (p < 0.02) whereas positivity for anti-MuSK antibody was a predictor of non-response (p = 0.0007). Conclusions: Thoracoscopic extended thymectomy yields satisfactory tong-term results in patients with nonthymomatous myasthenia gravis although anti-MuSK positivity correlated with poor response to operation. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.