Journal
EUROPEAN JOURNAL OF CANCER PREVENTION
Volume 19, Issue 3, Pages 204-215Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CEJ.0b013e32833720de
Keywords
angiogenesis; cervical carcinoma; human papillomavirus; immune response; stroma
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Funding
- Research and Projects Financing (FINEP)
- Support Research Foundation of State of Minas Gerais (FAPEMIG)
- National Council for Scientific and Technological Development (CNPq)
- Research and Teaching Foundation of Uberaba (FUNEPU)
- Belgian Cancer Foundation ('Stichting tegen Kanker')
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The carcinogenesis of cervical carcinoma implies an intricate interplay of neoplastic, human papillomavirus infected epithelial cells and stromal tissue, in which different factors have distinct but interacting influence. Persistent infection with an oncogenic human papillomavirus type may lead to epithelial dysplasia with progressive severity. To access the adjacent stromal tissue, tumour cells have to breach the basement membrane. The stroma partly controls tumour growth, invasion and angiogenesis. Last but not least there is considerable influence of the immune response. In this review we describe the importance of various stromal factors in carcinogenesis of cervical cancer. European Journal of Cancer Prevention 19:204-215 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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