Journal
EUROPEAN JOURNAL OF CANCER
Volume 47, Issue 2, Pages 163-174Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2010.11.005
Keywords
Core apoptosis; Cancer; miRNA; Chemoresistance
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Funding
- FCT [SFRH/BD/21759/2005]
- FCT, Portugal
- European Social Fund
- Fundacao Calouste Gulbenkian
- FCT, the Portuguese Foundation for Science and Technology
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Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance. (C) 2010 Elsevier Ltd. All rights reserved.
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