Journal
EUROPEAN JOURNAL OF CANCER
Volume 46, Issue 10, Pages 1773-1780Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2010.04.002
Keywords
Non-small cell lung carcinoma; Translocation; Kinase inhibitor; Clinical trial
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Funding
- National Institutes of Health [R01CA136851]
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The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK),has recently been identified in a subset of non-small cell lung cancers (NSCLCs). EML4-ALK is most often detected in never smokers with lung cancer and has unique pathologic features. EML4-ALK is oncogenic both in vitro and in vivo and ALK kinase inhibitors are quite effective in pre-clinical model systems. More recently ALK inhibitors have entered clinical development and remarkably clinical efficacy has been observed in NSCLC patients harbouring EML4-ALK translocations. This review will focus on the biology, clinical characteristics, diagnosis and treatment of EML4-ALK NSCLC. (C) 2010 Elsevier Ltd. All rights reserved.
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