Journal
EUROPEAN JOURNAL OF CANCER
Volume 45, Issue 9, Pages 1547-1553Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2009.01.029
Keywords
Neoplasm; Radiotherapy; Chemotherapy; Infertility; Ovary; Cryopreservation; Tissue banks; Transplantation
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Funding
- European Science Foundation
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Increasing survival rates in young cancer patients, new reproductive techniques and the growing interest in quality of life after gonadotoxic cancer therapies have placed fertility preservation as an important issue to oncologists, fertility specialists and patients. Several techniques are now available for fertility preservation in these patients. A new promising method is cryopreservation and transplantation of ovarian cortex. Ovarian tissue can be extracted by laparoscopy without any significant delay of gonadotoxic therapy. The tissue can be cryopreserved by specialised centres of reproductive medicine and transplanted in case the women experience premature ovarian failure (POF). This review summarises the European expertise on cryopreservation and transplantation of ovarian tissue, following around 30 reported transplantations globally, resulting in six live births and several ongoing pregnancies. It emphasises that fertility preservation by the cryopreservation of ovarian tissue is a new but already a successful clinical option, which can be considered for selected cancer patients. (c) 2009 Elsevier Ltd. All rights reserved.
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