Journal
EUROPEAN JOURNAL OF CANCER
Volume 44, Issue 13, Pages 1835-1840Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2008.05.026
Keywords
VEGF; bevacizumab; scintigraphy; colorectal cancer; live metastases
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Aim of the study: To investigate the correlation between tumour accumulation of In-111-bevacizumab and VEGF-A expression in patients with colorectal liver metastases. Methods: Two weeks before resection of the liver metastases 12 patients were intravenously injected with In-111-labelled bevacizumab. Ten minutes and 7 d after injection a whole body scan was acquired. Seven days after the injection, 3D acquisition SPECT of the liver was performed. Results: Enhanced uptake of In-111-bevacizumab in the liver metastases was observed in 9 of the 12 patients. The level of antibody accumulation in these lesions varied considerably. There was no correlation between the level of In-111-antibody accumulation and the level of VEGF-A expression in the tissue as determined by in situ hybridisation and ELISA. Conclusions: In this study, we investigated the correlation between tumour accumulation of radiolabelled bevacizumab and VEGF-A expression in patients with colorectal liver metastases. No clear-cut correlation between the level of antibody accumulation and expression of VEGF-A was found. (C) 2008 Elsevier Ltd. All rights reserved.
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